Top AI and ML Software Development Companies in 2025

In recent years, the integration of artificial intelligence in software has become the standard rather than something limited to a few projects.

The use of AI tools to reduce repetitive tasks and analyze customer behavior has become the new norm. Thus, collaborating with an agency that can help you seamlessly integrate AI into your workflow is key to success. 

For this article, we narrowed down the variants to the 5 most trusted partners for artificial intelligence development from the USA using such criteria:

• Presence of AI and custom software development services 
• Experience and recognition in the industry
• Genuine reviews from clients on reliable platforms
• Helpful and responsive customer support
• Transparency of pricing, practices, and communication

Continue reading to learn about the top AI and ML software development companies and what makes them stand out. 

Inoxoft 

As everybody would tell you, custom software development solutions require an expert hand, and Inoxoft is a prominent name in the industry that delivers on its promises. The company was first established in 2014, with its main office located in Philadelphia, USA. It also has several locations in Europe, ensuring its global reach.

Inoxoft is known for its wide selection of digital services. As part of the custom software development suite, Inoxoft works on desktop, mobile, and web applications of varied complexity.

A significant focus is on AI and ML technologies that are used for everything from virtual assistant creation to predictive analytics and chatbot development. You can also benefit from data science solutions, IT security infrastructure development, and UI/UX design. 

The outstanding professionalism of Inoxoft has been recognized by Clutch, as the company has frequently appeared on the lists of the top software and web developers. The team is also a Microsoft Gold partner, so they are well-versed in the latest advancements in algorithm development.

The company has delivered solutions for businesses in logistics, real estate, finance, healthcare, and fintech. Over the years, Inoxoft has completed hundreds of projects, and some of the company’s clients include Toshiba, EquineX, NIVEA, Vestel, UC San Diego, and more. 

GenAI.Labs

The next on the list of the best AI agent developers is GenAI.Labs. Founded in San Diego, California, GenAI.Labs boasts over 50 specialists on its team and has been in the game since 2016. 

It provides clients with innovative AI solutions for companies in a wide range of sectors. By working with GenAI.Labs, it’s possible to access ML product development, AI-powered web and mobile app development, GPT model integration, and more.

The track record of this agency includes hundreds of projects in a wide range of industries. By looking through their case studies, you will find prominent names in e-commerce, healthcare, retail, education, and logistics. Thus, the notable clients of GenAI.Labs are Ray-Ban, Gucci, and ServiceNow.

Sphere 

To continue the list of the top AI agent development companies, we should talk about Sphere. With a team of more than 200 employees, this Chicago-based company has been working in software development since 2005. In addition to the USA, Sphere has offices in Latin America and Europe.

The company offers full-scale digital transformation opportunities to its clients. The services offered include AI integration, data intelligence solutions, and elaborate software engineering. Moreover, you can benefit from mobile app development, staff augmentation, and IT consulting.

From insurance and banking to healthcare and agriculture, Sphere has helped clients navigate digital optimization. Some of the clients who worked closely with the agency include Clearcover and Hamilton Thorne. 

Six Feet Up

As we’ve compiled our list of the top AI&ML software development companies in the USA, we couldn’t pass by Six Feet Up. This agency was founded in Fishers, USA, and boasts extensive experience, having been in operation since 1999.

Six Feet Up offers all the services you may need for the successful integration of AI technology into your business. Clients can order machine learning and AI services, end-to-end mobile and web development, and cloud infrastructure tools.

The company has a personalized approach and develops custom solutions according to each individual’s specific needs. 

Over 50 employees are involved in development projects and serve a list of industries, including finance, nonprofit, government, education, energy, and more. As for the clients, the list features Capital One, NASA, and the University of Notre Dame. 

Oxagile 

Oxagile is another experienced company that was founded in 2005. It operates from its office in New York, USA, but also has employees working in Europe. Oxagile has a team of more than 400 experts for machine learning, AI, and other digital services, which ensures an extensive experience and fast delivery.

You can turn to Oxagile for end-to-end software development, whether you already have some solutions or you are starting anew.

The agency offers AI and ML development, predictive analytics, big data engineering, and scaling of web platforms. Oxagile is also heavily focused on video intelligence development, biometric analysis, and computer vision. 

Over its 19 years of work, the development agency completed more than 450 projects in healthcare, entertainment, AdTech, retail, sports, and more. The clients they worked with include Kaltura, Discovery Communications, and JumpTV. 

Final Thoughts 

Artificial intelligence and machine learning are becoming the pillars on which custom software development stands. This is not surprising, as it allows businesses to boost their workflow, improve decision-making, reduce costs, and more.

Thanks to these tools, companies can more easily identify what their clients need and recognize patterns in their behavior. 

However, to choose the right solution, you need to work in close collaboration with the best AI and ML software development companies. The teams on our list stand out with their professionalism, transparency, and dedication to giving each company a competitive edge.